In-silico-genotyping with BC/SNPmax

BC/SNPmax data management and analysis platform now includes workflows to easily impute more genotypes. Besides increasing the statistical power of association studies¹, in-silico-genotyping (imputing) can also be used to combine genome-wide data made on different platforms and reliably solve strand-orientation issues when combining datasets.

BC/SNPmax queue system and automated job segmentation enables computationally effective parallel imputation of genotypes (using IMPUTE ² or MaCH³), utilizing a large number of calculation nodes. The imputed genotypes can be saved back into the database and further analyzed, using for example PLINK⁴ or SNPTEST⁵, for which BC/SNPmax provides user-friendly web browser interfaces and result delivery work-flows.

In-silico-genotyping as a service

Biocomputing Platforms also offers in-silico-genotyping as a service, please contact us for more information (info@bcplatforms.com).

1) Carl A. Anderson et al, The American Journal of Human Genetics, Vol. 83, No. 1, July 2008
2) P Donnelly et al, Nature Genetics, 39:906-13 2007
3) MaCH home page
4) Purcell S. et all. (2007), PLINK: a toolset for whole-genome association and population-based linkage analysis, American journal of Human Genetics 81.
5) SNPTEST home page