Biopharma

Together with our clients, BC Platforms R&D strives to extend the lives of patients with any disease or illness. To advance this mission, we have built world-class software technology to be applied in novel science. Pharmaceutical companies use our software to connect patient health and genomic information to assist their drug discovery work or the workflows in clinical trial design. BC Platforms can help the pharmaceutical industry to locate suitable biobanks for collaborative discovery projects. Our BC|RQUEST software with advanced meta-analytics function facilitates creating new research hypotheses, as well as seeking genetic evidence for new drug candidates in different populations. With tens of thousands of genomes and the related clinical data we can transform large masses of data into proactive, preventative, and personalised treatments.

Use Case

BC|RQUEST is a modern ICT-enabled marketplace that brings together biobanks and pharmaceutical companies to engage in new forms of collaboration. BC|RQUEST is a service platform for pharmaceutical research teams, and biobanks to communicate with each other. The service provides data discovery users (research teams) with tools to browse and analyse the summary level information from data providers (biobanks), who have subscribed to the service. Biobanks connect their data collections to the service via a secure link that collects summaries of query results, never exposing the actual content. BC|RQUEST is a safe and confidential environment for pharmaceutical researchers to seek suitable patient cohorts within validated data cloud of multiple biobanks world-wide. The service gives both sides communication tools to conduct research proposals, coordinate collaboration, and request data and samples under DTA and NDA.
The BC|PIPE NGS implements automated workflow from NGS device output i.e FASTQ file (Illumina, for device other vendors all the features might not be supported) to (g)VCF to be stored to BC|GENOME. Two additional modules are available: BC|Q for tracking data quality, and security option for providing full log of data processing steps. For NGS alignment and variation calling pipeline, two options are provided: Microsoft Genomics Service or Sentieon software solution. BC|PIPE NGS implements fully automated, highly scalable NGS data secondary analysis pipeline.
BC|PIPE GT is a QC workflow tool designed for Illumina genotyping data. The tool analyses the quality of genotypes, samples, and chips creating a report of the items falling below QC thresholds. BC|PIPE GT also filters bad quality items, reporting them, and generating a genotype file ready for analytical processing in bioinformatics applications. BC|PIPE GT uses Illumina iScan devices' GTC file as input, utilising the EGT and chip manifest files for array structure and composition. This QC pipeline is designed to be implemented as part of a standard operating procedure for genotyping in laboratories.
BC|INSIGHT presents commonly used analytical and bioinformatics tools as easily accessible user interfaces. Bioinformaticians and analysts can create script-aided workflows utilizing either the off-the-shelf supported, peer-reviewed packages, or they are free to integrate in-house scripts (like R) and tools for the graphical user interface. BC|INSIGHT operates on data available via BC|GENOME platform, and relies of the platform's data integrity features. This creates a discoverable track chain of events for analytical tasks and projects. Users and administrators are able to rerun and iterate old analytical tasks, change parameters and data, and create repeatable, and traceable bioinformatics workflows.
BC|SAFEBOX is a security and confidentiality construct. It facilitates the analysis of sensitive patient data in environments where copying and exporting data or results is restricted. BC|SAFEBOX provides a secure server environment to perform research tasks as with BC|GENOME. In this environment the researcher is restricted into operating only within the platform, and in the immediate network connecting the platform to a calculation resource. Data and results can only be exported or sent out under distinct agreement between parties. The module provides a very high security environment in complex collaboration projects, isolating data analysis with technical means. BC|SAFEBOX can enable access to biobank data without moving it out from the biobank network, or from the country.
BC|GENOME is a data and research management platform for clinical genomic studies. The platform manages NGS, GWAS, PheWAS, variant analysis, linkage, and other data formats, and offers tools for complex queries in clinical and genetic data for multiple purposes. BC|GENOME scales up from small candidate gene studies to massive international collaboration environments. The platform is used to organise data projects, and to administer user and user-group access to sources. BC|GENOME provides fine-grained access management and auditing tools for building quality certified processes. BC|GENOME helps data and research managers to maintain and increase data integrity, quality, and efficiency of work. Flexible integration options allow access to external SQL and no-SQL sources, HL7 communications (EHR), cloud storage systems, and computational infrastructures (SunGrid, SLURM, Torque). All project data is managed in one location, sharing with other projects in a high-security environment.